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Monoclonal Antibodies with Broad Spectrum Activity against AI Virus Identified by NIH


A recent publication*described the isolation of three monoclonal antibodies (mABs) from a patient infected with H3N2 strain influenza.  These mABs demonstrated binding not only to the neuraminidase of the H3N2 strain but to other influenza viruses.  Subjected to mouse assay, the mABs inhibited NA proteins and protected recipients challenged with lethal doses of H3N2.


It is apparent that mABs may have a role in treatment of patients infected with influenza.  The studies conducted by the National of Institute of Allergy and Infectious Diseases provided insights into development of innovative vaccines.


* Stadlbauer et al. Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Science. DOI: 10.1126/science.aay0678 (2019).


Copyright © 2020 Simon M. Shane